It appears possible, although there is no supporting experimental evidence, that the high renal clearance of desglymidodrine a base is due to active tubular secretion by the base-secreting system also responsible for the secretion of such drugs as metformin, cimetidine, ranitidine, procainamide, triamterene, flecainide, and quinidine.

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Getting a skin rash that may include itchyredswollenblistered or peeling skin wheezing tightness in the chest or throat having trouble breathing or talking swelling of the mouthfacelipstongueor throat.

High insulin levels can cause thickening and darkening of the skinacanthosis nigricanson the back of the neckaxillaunder the armsand groin areaIn young women with PCOShigh insulin levels can cause the ovaries to make more androgen hormones such as testosteroneThis can cause increased body hairacneand irregular or few periodsHaving insulin resistance can increase your risk of developing diabetes.

Using certain diabetes drugs with metformin can cause low blood sugar levelsIf you start taking metforminyour doctor may reduce your dosage of your other diabetes medicationsExamples of these drugs include:

If you often forget dosesit may help to set an alarm to remind youYou could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

Metformin is usually the first choice of medicine prescribed to treat type 2 diabetes.

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